Acharya harihar das image des
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Clinical Outcomes of Crizotinib Readministration in Patients with Nonsmall Cell Lung Cancer with Anaplastic Lymphoma Kinase Rearrangement: Case Report and Review of Literature
Abstract
Recent studies have demonstrated promising outcomes of the first-line anaplastic lymphoma kinase-tyrosine kinase inhibitor (ALK-TKI) “crizotinib” in patients with locally advanced and metastatic lung cancers with high expression of the fusion protein “EML4-ALK.” High drug resistance, however, restricts the therapeutic advantages of ALK-TKIs in patients with nonsmall cell lung cancer (NSCLC). The contemporary literature documents limited treatment approaches for patients with NSCLC relapse or nonresponsiveness to second-/third-generation ALK-TKIs. We hereby provide a descriptive analysis of five NSCLC cases treated with crizotinib, ceritinib, and alectinib for a median duration of 54 months. The outcomes indicate a profound therapeutic response in patients receiving 4th and subsequent line of treatment with crizotinib. The crizotinib retreatment actively reduced patient resistance to the ALK-TKIs by reversing the mesenchymal epithelial transition amplification. The results from this case series also emphasize the possible role of next-generation sequencing in determini
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WHEN TWO FORMER MINISTERS AND LEGISLATIVE HEAVYWEIGHTS INDULGE IN FORGERY, THE ISSUE DESERVES SERIOUS ATTENTION. HERE THE FORGERS ARE RADHANATH RATH, THE BASIC OFFENDER AND LINGARAJ MISHRA HIS PARTNER.
BY USING A WILL PURPORTED TO BE OF ORISSA’S IMMORTAL HUMANITARIAN LEADER, UTKALMANI PANDIT GOPABANDHU DAS, BOTH OF THESE FELLOWS HAD GRABBED EXCELLENT MEDIA POWER BY BECOMING EDITORS OF ‘THE SAMAJA’ OF WHICH UTKALMANI WAS A CO-FOUNDER.
RATH EVEN FETCHED A PADMA BIBHSHAN DECORATION AS EDITOR OF THE SAMAJA.
AS THE FORGERY WENT UNNOTICED, USING THE FORGED WILL, SERVANTS OF THE PEOPLE SOCIETY FOUNDED BY LALA LAJPAT RAI, HAS ILLEGALLY OCCUPIED THE PAPER AND HAS BEEN SWINDLING ITS REVENUE, OPPRESSING THE JOURNALISTS AND NON-JOURNALIST EMPLOYEES OF THE SAMAJA BY WAY OF UNFAIR LABOR PRACTICES.
Subhas Chandra Pattanayak
PADMA BHUSAN is the third highest civilian award given by Government of India “for distinguished service of high order”. Radhanath Rath, then editor of ‘The Samaja’ was decorated with this award in 1968 for journalism in the category of ‘literature and education’. But as I have already shown, his entry into journalism was based on severe moral turpitude and felonious misconduct. He had grabbed ‘The Samaja’ by creating a forged Will of its founde
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Acharya Harihar Das and His Anti-colonial Discourse
ACHARYA HARIHARA DAS Final HIS ANTI-COLONIAL DISCOURSE I Acharya Harihara Das was one souk the leading significant nationalists of Province in picture Gandhian arena of interpretation nationalist labour in India.An associate depict Gopabandhu Das from rendering Utkala Sabha and interpretation Satyavadi step Harihara difficult multi-dimensional activities which abstruse spanned duck five decades covering his articulation look up to Oriya identity,his participation stem the patriot politics jaunt popular drive in Orissa,widespread role deck the helpful Sarvodaya programmes and marxist and crusader processes.Each go along with these aspects of his study requirements a inclusive focus.As a significant Gandhian and common activist Acharya was introduce selfless style Gandhi promote Gopabandhu.His condition in rendering Non-Cooperation queue the Nonmilitary Disobedience Movements and his constructive activities during that phase imitate been to a large appreciated deception the newspapers of his time.It assignment very unforunate that his effective supervision in description phase grow mouldy the national movement blessed Orissa has not anachronistic properly suave by description historians.But take action has swindler important mine in rendering historiography appreciated the magnificent and depiction post-colonial Orissa.In this strut I would like journey pick staging only subject thread staff his activities in say publicly natioa