Jeffrey clayton goodell biography examples
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Clayton Page Aldern is a writer and data scientist interested in science and society. His writing has been published by The Guardian, The Atlantic, The Economist, Logic, Grist, and others. His reporting and data visualization have been syndicated or otherwise republished by The New Republic, Mother Jones, Vox, and elsewhere. Aldern has worked in computational neuroscience, homelessness policy, and environmental journalism: currently as a senior data reporter at Grist. He also serves as a research affiliate of the University of Washington's Center for Studies in Demography and Ecology. He holds a master's in neuroscience and a master's in public policy from the University of Oxford, where he studied as a Rhodes Scholar. He is a Reynolds Journalism Institute Fellow, a Seattle CityArtist, and a Climate Reality Leader, among other honors. He conducted his undergraduate work in neuroscience at Brown University. You can get in touch on Twitter @compatibilism.
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Abstract
Simple Summary
Breast cancer stem cells are blamed to be responsible for breast cancer tumorigenesis, metastasis, drug resistance and tumor recurrence. Therefore, it is critical to identify this subset of cells and understand their molecular mechanisms for the development of breast cancer treatment strategies. Here, we review the recent advances in breast cancer stem cell studies in terms of available biomarkers, identification and isolation methods, molecular mechanisms, and methods for studying their cellular origin and lineage development.
Abstract
Despite recent advances in diagnosis and treatment, breast cancer (BC) is still a major cause of cancer-related mortality in women. Breast cancer stem cells (BCSCs) are a small but significant subpopulation of heterogeneous breast cancer cells demonstrating strong self-renewal and proliferation properties. Accumulating evidence has proved that BCSCs are the driving force behind BC tumor initiation, progression, metastasis, drug resistance, and recurrence. As a heterogeneous disease, BC contains a full spectrum of different BC subtypes, and different subtypes of BC further exhibit distinct subtypes and proportions of BCSCs, which correspond to different treatment responses and disease-specific outcomes. This review su
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