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Zig Ziglar is internationally renowned speaker and authority on high-level performance.

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The Cruel Stars of rendering Night

May 11, 2015

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About a moon after desert disappearance, phenomenon have interpretation

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The Ian McEwan papers consist of drafts (typescripts, printouts, electronic files) of published and unpublished works, personal and professional correspondence, notebooks, photographs, clippings, and family papers from English novelist Ian McEwan. The professional and personal papers document McEwan's diverse writing career and range of creative output including novels; short stories; essays; lectures; scripts for radio, television and stage; screenplays; and libretti. The papers are organized into five series: I. Works, 1969-2013, undated; II. Correspondence, 1968-2014, undated; III. Personal and Professional, 1930s-2014 (bulk 1974-2013); IV. Works by Others, 1976-2012, undated; and V. Serials and Publications, 1973-2014.The materials arrived at the Ransom Center in labeled A4 size document storage boxes and the arrangement outlined here closely reflects McEwan's original record organization.Additionally, one computer hard drive containing document files, email correspondence, and photographs, as well as twelve computer disks are included in the material. Many of McEwan's writings (including novels, screenplays, essays, and lectures, as well as unidentified documents), outgoing correspondence, photographs, a

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Abstract

Introduction:

HIV-infected individuals have evidence of intestinal microbial translocation which is associated with immune activation and unfavorable clinical outcomes. Rifaximin, a non-absorbable antibiotic which reduces microbial translocation in other disease states, was shown to have a marginal beneficial effect on microbial translocation, T-cell activation, and inflammation in a multisite randomized trial (ACTG A5286; NCT01466595) of HIV-infected persons with poor immunologic recovery receiving ART. Here, we report analysis of the rectal microbiome changes associated with that trial.

Methods:

HIV-1-infected individuals receiving ART with CD4-T cell count < 350cells/mm³ and viral suppression were randomized 2:1 to rifaximin or no therapy for 4 weeks. Rectal swabs were collected at baseline (pre-treatment) and at week 4 of rifaximin therapy. Genomic DNA extracted from rectal swab samples was analyzed using high throughput sequencing and quantitative PCR of bacterial 16S ribosomal RNA (rRNA) genes.

Results:

Forty-eight HIV-infected participants (31 received rifaximin, 17 no treatment) were included. There was broad variability in the recovery of bacterial rRNA from the specimens at baseline. No major significant (FDR P < 0.05) effects of rifaximin tr