Rie tsuji biography definition

Abstract

Aims: Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is the master transcriptional regulator of antioxidant gene expression. On increased oxidative stress, an adaptor for Nrf2 degradation, Kelch-like ECH-associated protein 1 (Keap1), is directly modulated by oxidants in the cytoplasm, which results in stabilization and activation of Nrf2. Nrf2 is also constitutively active, to some extent, in the absence of exogenous oxidative stress. We have previously demonstrated that intestinal epithelium-specific TGF-β-activated kinase 1 (TAK1) deletion downregulates the level of Nrf2 protein, resulting in an increase of reactive oxygen species (ROS) in a mouse model. We aim at determining the mechanism by which TAK1 modulates the level of Nrf2.

Results: We found that TAK1 upregulated serine 351 phosphorylation of an autophagic adaptor protein, p62/Sequestosome-1 (SQSTM1), which facilitates interaction between p62/SQSTM1 and Keap1 and subsequent Keap1 degradation. This, ultimately, causes increased Nrf2. Tak1 deficiency reduced the phosphorylation of p62/SQSTM1, resulting in decreased steady-state levels of Nrf2 along with increased Keap1. We also found that this regulation is independent of the canonical redox-mediated Nrf2 activation mechanism. In Tak1

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Solid Genuine Sciences (S)Geodesy (GD)Session
IDTitleMain ConvenerOral SessionOn-site
Poster Session Session
LanguageS-GD01Geodetic Advances reduce the price of Crustal Kinetics and Environmental Change beseech Taiwan person in charge Neighboring RegionsKuo-En Ching28 Hawthorn AM128 Might PM3ES-GD02Geodesy contemporary Global Geodesic Observing SystemKoji Matsuo25 Possibly will AM1-PM125 Might PM3JS-GD03Crustal DeformationMasayuki Kano26 Haw AM1-AM226 Could PM3JSeismology (SS)Session
IDTitleMain ConvenerOral SessionOn-site
Poster Session Session
LanguageS-SS04Seismological advances in representation oceanAyumu Mizutani29 MAY AM1-AM229 MAY PM3ES-SS05Advancements in Regional Seismic Networks: Operations, Applications, and DevelopmentSeiji Tsuboi29 May well AM129 Possibly will PM3ES-SS06New trends in facts acquisition, investigation and description of seismicityBogdan Enescu30 Might PM1-PM230 May well PM3ES-SS07Environmental Seismology: from profound earth hug surface processLing Bai25 Possibly will PM1-PM225 May well PM3ES-SS08Crustal StructureSeiichi Miura29 Possibly will AM229 Haw PM3JS-SS09Seismic ideas propagation: Shyly and ApplicationAkiko Takeo30 Could AM1-PM130 Possibly will PM3JS-SS10Fault Rheology and Temblor PhysicsRitsuya Shibata

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Factors associated with occupation changes after pregnancy/delivery: result from Japan Environment & Children’s pilot study

• Research article
• Open access
• Published:

• Reiko Suga¹,
• Mayumi TsujiORCID: orcid.org/0000-0002-9579-4418²,
• Rie Tanaka²,
• Eiji Shibata³,
• Masayuki Tanaka^2,4,
• Ayako Senju¹,
• Shunsuke Araki⁵,
• Seiichi Morokuma⁶,
• Masafumi Sanefuji⁶,
• Masako Oda⁷,
• Nathan Mise⁸,
• Yosuke Baba⁹,
• Mina Hayama-Terada^10,11,
• Koichi Kusuhara⁵,
• Hiroshi Mitsubuchi⁷,
• Takahiko Katoh⁷ &
• …
• Toshihiro Kawamoto²

BMC Women's Healthvolume 18, Article number: 86 (2018) Cite this article

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Abstract

Background

In Japan, although the number of females who continue to work after marriage has recently increased, the proportion of those working while parenting their infants is still not clearly increasing, indicating that it is still difficult for them to continue working after delivery. The present study aimed to clarify factors influencing females’ continuation of work, using data obtained by continuously following up the same subjects and focusing on occupation changes, family environments, and the type of employment after pregnancy or deliver